The concept of half-life is not unique to the use of anabolic steroids.
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It is used in many scientific fields such as physics, chemistry, biology, etc. In medicine and more specifically in pharmacology, the half-life is an essential factor in the development of drug dosage. Regardless of the field in which this theme is used, it tends to say the same thing in the background. Thus, in a general way, the half-life is a brief period during which something blossoms before disappearing. In physics, more precisely in the field of radioactivity, it is the time required for half of the atoms of a given quantity of a radioactive substance to decay.
Since anabolic steroids are drugs, we will stick to the half-life in pharmacology. What is the half-life of a pharmaceutical product?
The half-life in pharmacology: anabolic steroids in particular
In pharmacology, the half-life of a substance administered to a living being is the time necessary for the activity of this substance in the body to be reduced to half of its initial effectiveness . All drugs have a half-life. If we take the case of anabolic steroids, their half-life is the time during which they remain active in the body until they lose in half their efficacies. This notion is very important to understand. This will allow you to make good product planning throughout your cycle. Without an adequate understanding of the half-life of the anabolic steroids you use, the chances of you doing inappropriate dosages are very high. In the best case, the doses will be lower than normal and you will not be able to reach the set targets. In the worst case, the risk of overdose is very high. So you will be exposed to all the side effects of anabolic steroids and more.
The half-life of a substance should never be seen as the full life of this substance. Nor should it be confused with average life. Many people make the mistake of confusing these different themes.
The half-life may vary from one steroid to another. What are the factors that can influence the half-life of anabolic steroids?
Why do not anabolic steroids have the same half-lives?
The half-lives of anabolic steroids depend on several factors. Already, anabolic steroids are not all designed in the same way and even less with the same compounds. On the basis of this, it is impossible for all anabolic steroids to have the same half-lives since they will not have the same resistance to human metabolism. There are several factors that can affect the half-life of these products. The most important factors are as follows.
The route of administration
The route of administration has a significant impact on the half-life of an anabolic steroid. Oral and injectable anabolic steroids are the most commonly used. There are many other ways such as transdermal patches, gels or creams, implantation lozenges, and sublingual and nasal applications. However, they are very rare.
Anabolic steroids to be administered orally generally have short half-lives compared to injectables. This is because these types of anabolic steroids are ingested in their pure states and are therefore immediately active. The oral route does not allow to set up a mechanism such as esterification to delay the release of steroid hormones in the body.
The other reason why the half-lives of oral anabolic steroids are much shorter than the half-lives of injectable steroids is the immediate exposure to hepatic metabolism. At this level, the liver accelerates the metabolism and promotes the absorption and / or rapid elimination of hormones. The half-lives of oral anabolic steroids are between 4 hours to 48 hours, depending on the anabolic steroid used. There are of course exceptions.
Injectable anabolic steroids generally have longer half-lives than oral steroids. Injectables are specially formulated to form deposits in the muscular areas where they are injected. As a result, these deposits slowly dissolve from the injection site to the blood system. This slow release allows steroid hormones to remain active for much longer periods of time than oral anabolic steroids . There are two types of injectable anabolic steroids. Those based on oil and those based on water. Oil-based injectables are much more apt to form deposits. The half-lives of injectable anabolic steroids usually vary from 24 hours to 15 days or more, depending on the anabolic steroid used. Almost all injectable anabolic steroids are esterified.
Esterification has been specially developed by scientists to extend the half-life of injectable substances. This is a very decisive factor in the prolongation of the half-life of anabolic steroids. Esterification is a process by which a carboxylic acid binds to the 17-beta hydroxyl group of an anabolic steroid. The carboxylic acids that are esterified have varying lengths and are in the form of a carbon chain. The longer the carbon chain of the carboxylic acid, the longer the half-life of the anabolic steroid will be prolonged. Once the anabolic steroid is injected into the body, it is slowly released from the injection site to the bloodstream, and once in the blood, the esterase enzymes of the body break down the ester of the anabolic steroid. Longer ester bonds will require more time for these enzymes to release the hormone from the ester.
Some examples of steroid half-lives:
Here, for example, are the half-lives of the main oral steroids:
- Dianabol : 8 hours
- Anavar : between 9 and 12 hours
- Primobolan : 6 hours
- Winstrol : 8 hours
Below are the half-lives of the main injectable steroids:
- Winstrol : 24 hours
- Primobolan : 10.5 days
- Boldenone : 15 days
- Déca-Durabolin : between 6 and 15 days
- Parabolan : 6 days
The half-life is a key concept to master when you want to take a course of anabolic steroids or when you are already a user . This concept will help you achieve an effective schedule of products to achieve your goals and plan your post-recovery recovery.