Insulin in Bodybuilding

Insulin in Bodybuilding

Insulin promotes the diffusion of glucose into the cells via the insulin receptor.  Very high concentrations of insulin result in protein synthesis by the strongly stimulated muscle.


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Insulin is a protein secreted by the pancreas which acts on the liver to stimulate the formation of glycogen from glucose and to inhibit the conversion of non-carbohydrates into glucose.

Insulin also promotes the diffusion of glucose into the cells via the insulin receptor.  Very high concentrations of insulin result in protein synthesis by the strongly stimulated muscle.  It does so mainly by improving the initiation of the peptide chain.

These results make it incredibly useful to bodybuilders and athletes.  And those factors combine to make ingested protein more efficient by promoting the transport of amino acids into muscle cells.

We can clearly say that insulin is undoubtedly essential for anabolic muscle tissue.  It also increases bone density. Another mechanism increasing the anabolic effect of insulin is that insulin increases the levels of IGF (Insulin in your body. No need to remind you that IGF-1 is a highly anabolic hormone.

Another unexpected aspect of insulin is its ability to increase LH levels (Leutenizing hormone) and FSH (Follicle Stimulating Hormone). This means that insulin stimulates gonadotropin secretion, it has an anabolic effect by increasing your  HPTA (hypothalamic-pituitary-testicular-Axis) ability resulting in the increase of your testosterone production.

Insulin also increases the binding capacity of anabolic steroids with the androgen receptors, which strongly suggests the possibility of a synergistic effect of insulin when combined with steroids. Most bodybuilders confirm that insulin has an anabolic synergy when combined with the growth hormone.

injection insuline

The relationship between insulin, IGF and HGH is very synergistic and interdependent from each other actions. Using all three together, plus anabolic steroids and a fat burner will give you the most powerful and solid muscle possible.

Of course, when something seems too good to be true, there is always a but !!!!

Unfortunately, the bad news is that insulin can easily stimulate the storage of body fat.


Generally, most bodybuilders take insulin with a fat burner or thyroid hormones such as t3-Cytomel, as well as anabolic steroids and sometimes even HGH and IGF, for reasons explained previously. All this decreases the probability of fat storage, and greatly increases the amount of muscle that will be gained.

The individual insulin needs are usually between 0.3 and 1.0 IU / kg / day. Make sure your insulin is limited between 15 and 45 IU. But this will depend greatly on your daily carbohydrate intake. During a diet or cutting period, the dosage should be reduced more. Most bodybuilders use up to three insulin injections daily.


  • The first dose of the product just after waking up.
  • The second dose of the product somewhere near noon.
  • The third and final consumption is done right after you finish your workout for the day.


Actrapid HM Penfill Novo Nordisk Fast Insulin



Normally, insulin is produced by the pancreas and is then discharged into the blood. It acts in seconds, and its production, so-called secretion varies every moment depending on the needs of the body. This so-called fast insulin or regular insulin Actrapid HM Penfill, is produced in the lab, which is identical to the insulin produced naturally by the human body.

But although we know how to perfectly make this insulin in the laboratory, we do not know (yet) how to control the discharge into the blood by varying the rate at all times as required. This is the great problem of its administration route, to know how it will be able to get into the bloodstream.

As it is destroyed when it passes through the stomach, the insulin can not be taken as a tablet or a drinkable ampoule. The only way that is used is the famous bite of insulin, which is made by an injection under the skin (subcutaneously). But once the insulin is under the skin, it has to travel to the blood vessels and this takes time. This is why the rapid called insulin finally comes rather slowly. Its action begins 15-30 minutes after the injection and lasts about 6 hours.

Humalog Lilly Novo Nordisk Fast Insuline

humalogTo counter the problem of fast acting insulin acting too slowly compared to the rapid influx of carbohydrate meal, we have sought to develop insulin that acts even faster.

The researchers were able to slightly change the structure of insulin and have successfully developed a modified insulin that works faster, stronger and in less time: it is the “fast insulin analogs” like insulin HUMALOG.

Following subcutaneous administration, Humalog has a rapid effect and a shorter action duration (2-5 hours)  than regular insulin. This quick action enables the administration of an injection of Humalog (or in the case of a subcutaneous continuous, a Humalog bolus) shortly before or after the meal. The evolution of action time of any insulin may vary significantly from one subject to another or at different times in the same subject.  The onset of action, faster compared to rapid human insulin, is maintained regardless of injection site. As with all insulin preparations, the action of Humalog duration depends on the dose, site of injection, blood supply, temperature and physical activity


Insulatard Penfill Novo Nordisk slow insulin

Regular insulin has a duration of action of approximately 6 hours. To achieve the effects of 12 to 24 hours, researchers have developed longer-acting insulins. They had the idea of adding to insulin crystals in a product called Protamine: when injected subcutaneously, insulin stands slowly and thus acts longer. Thus the NPH as Insulatard was born.

This is an identical insulin to human insulin, obtained by biotechnology. Its duration of action is long: its effect is approximately 1 hour 30 minutes after injection and fades after 24 hours. Insulatard is often given in combination with fast-acting insulins.

This insulin should only be injected subcutaneously while varying the injection sites to avoid the appearance of lipodystrophy (nodules and thickening of the skin).

Before the injection, stir the suspension by flipping it to homogenize.

For a better comfort, insulin can be removed from the refrigerator an hour before the injection or warmed in the hands for a few minutes and then injected at room temperature.

In case of sports, it is better to inject the insulin at a site that is far from worked muscles during training, to prevent a too rapid absorption.



Mixtard 30 HM Penfill Nordisk Mix slow and fast insulin

insuline-Mixtard-30-HM-PenfillTo avoid multiple injections of insulin, the researchers had the idea to mix slow insulin (NPH) and insulin (Actrapid).

This mix of insulin is called Mixtard (Novo Nordisk)

Mixtard is a mixture of fast-acting and long-acting insulin. This means that it will start to lower your sugar levels in the blood half an hour after administration with effects lasting about 24 hours.


Administration of insulin



Insulin is usually administered by subcutaneous route at the level of the abdominal wall. Injections may also be made in the thigh, the gluteal region or the deltoid region.

An injection through subcutaneous route in the abdominal wall ensures a faster absorption than other injection sites.

The injection into a skin fold minimizes the risk of unintended intramuscular injection.

After the injection, the needle must remain in the skin for at least 6 seconds to ensure the injection of the full dose.

The injection zone is determined by the type of insulin to be injected. …


Special precautions for insulin conservation 

Store between + 2 ° C to + 8 ° C (in the refrigerator), away from the freezer compartment.

Do not freeze.

Keep container in the outer carton to protect from light.

During use: do not refrigerate.

Do not store above +30°.

Keep away from excessive heat and light


Duration of insulin conservation

Put unused insulin cartridges in the fridge until you need them. You can use them until the expiration date printed on the label. Avoid freezing.

You can keep opened insulin at room temperature, but then discard it after 28 days.

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