Inhibiting Myostatin

Inhibiting Myostatin

Myostatin in particular, is a protein that limits muscle tissue growth so that the muscles do not grow excessively.  It gives us the physical aspect that we call “normal”.  Surpassing yourself, reaching your limits are the motivation driving all of our battles in the gym.

 

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Surpassing yourself and reaching your limits are the generals driving all the warriors. Surpassing your physical limits can only be achieving by first hitting your physical limits, which for a regular gym junkie, is unfortunately inevitable. However our bodies are primarily machines that can go beyond the genetic code.  The barriers it can face will be multiple, and only the mind can harness the strength and willpower needed to push through these obstacles.  Many foods called tonics are necessary for the proper functioning of our body and to give it the energy it needs to push ourselves past our predetermined limits.  It is essential to consume food several times daily over a long period. This path is long and without short term, direct effect.

The bodybuilder is an athlete like any other. His muscular structure is exploited to the fullest.  His architecture is carefully designed and purpose driven. The effort is more intense and requires an above normal nutrient intake.

The bodybuilder remains unique.  The work done is meticulously calculated and demands great rigor.  This precision of work requires constant and daily concentration.

Metabolism is perpetually biased even during sleep.

The bodybuilder’s body is constantly boiling: calories are burned on a large scale and the organism is in excessive demand for nutrients.

Many useful supplements and compounds should be utilized.  Regular consumption of these products effects the biological balance of our body and helps create the optimal conditions in our body for muscle growth and strength gain.

 Also it is essential to change your eating habits to benefit from the contributions of these products.

This is why through scientific research and animal experiments, a new generation of advanced products have revolutionized the sports world. Many derogatory attitudes hover around this phenomenon, and rumors quickly did their job as usual, without research and scientific fact.

The word “doping” is itself  loaded with critical guilt that pushes the athlete into hiding, without considering the therapy option.  These products answer to a strong demand for athletes and bodybuilders’ physical support .

Of course like anything else there are uncontrollable drifts due to the need for secrecy and also individuals lack of caution.

 

Myostatin

In ancient times, athletes were already using mixtures of plants known as “explosive cocktails” that allowed them to achieve the performance and physique of a superman.

Nowadays microscopy delivers us the secrets contained in these molecules, to our body.

Myostatin in particular, is a protein that limits muscle tissue growth so that the muscles do not grow excessively and they give us the physical aspect that we call “the norm”.

Each individual is unique in his own self and physical appearance.

Nowadays homogeneity prevails and everyone wants to look like everyone else (fads, Hollywood, hyper consumption …)

But the over-development of the muscle is necessary to sportsmen wishing to increase performance while keeping hard work and intensive training.

street workout finger pushups

During physical training or during competition, and even during recovery, Myostatin is a molecule naturally secreted by skeletal muscle cells during body development.  In adulthood, it controls the repair and growth of muscle by blocking the proliferation of muscle cells.

Let’s see a concrete example. When the athlete has had a tear or followed an intensive muscle building program, the healing of damaged muscle goes through the activation of skeletal cells of Myostatin.

The control of muscle growth is made by a muscle crack which generates inflation represented by a cell disruption that releases molecules.

Then comes a cascade of signals involving satellite cells creating the proliferation and development of new muscle fibers that are bigger and stronger. the Myostatin regulates the muscle fiber size but not their number.

This process continuous until the muscle receives a signal to stop its growth.

Then the Myostatin prevents the activation of satellite cells to stop the growth of muscle. Note that this phenomenon only affects skeletal cells and therefore the heart muscle is not subjected to this operation.

This is why inhibiting Myostatin is necessary and beneficial to achieve your goal of muscular force expansion.

evolution chart

 

How and why to inhibit Myostatin?

Several methods are possible, having the aim of preventing the connection between the Myostatin and its receptor called activin IIB (ActRIIB).

By its methods the activity of myostatin will be blocked and muscle growth will not be halted.

role myostatine activine

Follistatin and ACE-031 

The methods are to entrap the active Myostatin by the antibodies and stop it binding to the receptors.

Or inactivate a pro synthetic peptide. Or increase the expression of natural inhibitors of Myostatin such as Follistatin.

Or finally, to make inactive receptors of Myostatin fixed on skeletal cells.

The molecules used may be endogenous or exogenous. The endogenous molecules have a role in modulating the Myostatin activity.

These molecules are called among others, Follistatin.

 

follistatin

Follistatin is a peptide present in human serum, it naturally inhibits Myostatin.

This molecule binds to myostatin circulating in the serum and prevents its binding to the receptor.

It is the receiver at the outer cell membrane, so the Myostatin does not reach other cells.

Follistatin is synthesized at the gonadotropic cells but also at the folliculostellate cells in the anterior pituitary.

But it is also produced in other cell types.

Its inhibitory role affects the amount of Myostatin attachable to the activin receptor.

On the other hand there is also the protein pro peptide ACE-031  (ACVR2B) a synthetic molecule produced by linking a part of the receiver to a portion of the human antibody.

This method blocks the receptors of Myostatin by directing antibodies against it.

The pro ACE-031 peptide (ACVR2B) the inactive synthetic Myostatin by its maintenance. Then the pro peptide is detached from the inactive Myostatin and the latter is fixed to the skeletal muscle cell by the receiver. Knowing that Myostatin is inactive, it no longer limits muscle growth.

 

Cases related to the Myostatin hypertrophy.

As explained above, the Myostatin has a regulating effect on muscle mass. But in the 90s a Myostatin mutation disturbing the metabolism of animals, especially cattles, was detected.  This mutation called “Belgian Blue” did not stop muscle growth in animals and their muscle mass increased considerably. This phenomenon is called hypertrophy and has adverse health consequences by low levels of collagen, a high proportion of fast glycolytic fibers and low fat deposition. Therefore animals are tired, more receptive to respiratory diseases, with decreased fertility and increased calving difficulties.

leg baby myostatinOn the other hand, a more than surprising case was recently discovered in a three-year-old child. Liam Hoeksra, A German child living in America, he is like any other child except that he is capable, since his first months, of incredible feats. Like carrying dumbbells that are a third of his weight or performing abdominal crunches at full speed, among others.

Carrying a rare genetic mutation that affects his susceptibility to Myostatin, this child has a 40% more muscle mass than normal.

Unlike animals the hypertrophy that Liam has suffered has no bad effect on his health. Indeed Liam has a fast metabolism, little fat and extraordinary strength. All that a high-level athlete could ever dream of.  Great hopes for the use of blocking Myostatin rest on this child.

 

Myostatin Clinical studies

dog myostatine

Although the case remains rare, substantial clinical studies on Myostatin are being tested on animals and humans.  But some studies have already been published on muscle function in the absence of Myostatin.

Experiments on mice lacking Myostatin reveal that despite bigger muscle mass, the maximum force is not increased but diminished. It has been certified that animals with a Myostatin deficiency lose oxidative fibers  in favor of glycolytic fibers.

rat myostatineOn one hand, the effect of this fibers conversion on muscle function and exercise capacity are not known. Therefore laboratories are studying the possibility to reverse this process by specific muscle exercises.

All of the studies observed an increase in muscle mass after blocking Myostatin.  The increase in the amount of force produced was calculated.  These results are promising and support the interest of therapy for the blockage of Myostatin.

On top of that, this effect is not only beneficial for the muscle increase but also results on the complex interaction of other tissues allowing the improvement of the muscular architecture.

On the other hand the blockage of Myostatin has therapeutic virtues on many muscle diseases such as muscular dystrophy.

It was also shown that the deactivation of the Myostatin has a direct impact on cancer cells for a longer lifespan of the patient. Especially in carriers of colon cancer.

 

Conclusion: Myostatin Studies will make us supermen?

With the Myostatin research currently being performed, we can be certain that it is a mutant molecule capable of changing to double the capacity of the muscular system.

Have we been gradually genetically modified  for the progress of humanity? Our genetic code will evolve to the point that the strength of our brain will take the place of the strength of our muscles?

Many questions remain unanswered like the construction of Egyptian pyramids on a desert floor by the force of men.

Has our body adapted to our life conditions?

Genetics is already on the front of the scientific stage. The scientific world is in full boil and the experiments that used to be improbable are emerging now, thanks to modern technology.

A promising future which encompasses the phenomenon of the modifiable Myostatin. Modern technology will increasingly intensify and allow science to elucidate the mysteries of our body with the time. Will man’s future will be inspired by fiction?  Will the heroes of our childhood be the men of tomorrow? Everything is possible.  But what is certain is that the human body has an infinite adjustment of force.  Life expectancy has increased during the last century.  Food diversity through globalization predestines us to a better food knowledge.  The medical world shares its research and knowledge internationally.  And the comfort of modern life makes us take better care of our bodies.

 

Nowadays the great megalopolises favors individualism. “One for all and all for one” is completely gone. “Every man for himself” took its place.

body myostatineA paradoxical social life, where excessive density melts in solitary lives, the neighbor has become invisible as we communicate online at a distance.  Modern life is rushing by at a hundred miles an hour.  It divides us and makes us strangers face to face.

Due to this, a feeling of insecurity intensifies and grows foresight.

A world where the law of the strongest is in process.

Will the ancient law of the jungle still reign in the world of tomorrow? Perhaps, but this group abstraction should awaken us to take precautions.

What better security than knowing how to rely on oneself.  Beyond the material aspect (car, house, money) that feeling of self satisfaction, confidence expansion in itself can be acquired by controlling the body and the mind.

 

The athlete already prevails and comes out if the blocks running. His mentality of beating out from the crowd and excelling is a solid and indestructible routine.

He is aware of the world he lives in and the confidence is difficult for him to give.  This individual will of course, seek to develop his physical and mental strength.  To become ever increasingly strong.

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